ABSTRACT
Introduction: Knowledge of position of nutrient foramina of long bones can be useful in certain surgical procedures. Bone ossification, growth and healing depend on its vascularity. Nutrient artery is the main source of blood supply of bone along with periosteal arteries. The topographical knowledge of these foramina is useful in certain operative procedures, in orthopedics as well as in plastic and reconstructive surgeries.AIM: The present study aims to determine the number and position of nutrient foramen of tibia and fibula and to observe direction and obliquity of nutrient foramina. Subjects and Methods: 100 adult dry bones including 50 tibia and 50 fibula were studied. Nutrient foramina were identified with naked eyes. The obliquity was determined with hypodermic needle. The nutrient foramina location was determined by dividing total bone into segments, the locations were validated by calculating foraminal index. Results: It has been observed that 98% (49) tibia has single nutrient foramina, double nutrient foramiana present in 2%of tibia. Most of the nutrient foramina in tibia are present in upper third i.e 65%(33).Foramina index of tibia is 45.05 with standard deviation of 8.29.In fibula single foramen was observed in 46(92%) and double foramina 2(4) and there is no nutrient foramen in 2(4). In 2 fibulae having double nutrient foramen, proximal foramen was directed downward and distal foramen was directed upwards. In 50%(25) nutrient foramina is present in posterior surface,most of nutrient are in middle third 48(96%).mean foraminal index of fibula is 45.05 with standard deviation of 8.29. Conclusion: Our study has attempted to put together findings from different studies regarding the number and position and obliquity of nutrient foramina of leg bones .The present study will be useful for orthopedic surgeons during procedures like bone grafting and more recently microsurgical vascularised bone transplantation and new graduates to understand the importance of nutrient foramina of long bones.
ABSTRACT
Cyclophosphamide (CP) is a commonly used chemotherapeutic and immunosuppressive agent which is used in the treatment of wide range of cancers and autoimmune diseases. Besides that it is a well known carcinogen. In this study by using chromosomal aberrations (CA) and sister chromatid exchanges (SCE) assays method, the modulatory effects exerted by the extract of garlic against the CP induced genotoxicity in the human lymphocyte cultures in vitro were tested. Three different doses of garlic extract were tested for their modulatory capacity on the mutagenecity exerted by 100 µg ml-1 of CP. The results indicate a significant decrease in the frequency of CA and SCE suggesting that the garlic extract modulates the CP induced genotoxicity in a dose dependent manner. These findings provide the future directions for the research on design and development of possible modulatory drugs containing garlic extract.
ABSTRACT
The objective of the present study was to evaluate the protective effect of Phyllanthus emblica against clastogenicity induced by lead nitrate on the incidence of sperm head abnormalities in the germ cells of mice. At higher concentration of lead, a significant increase in the percentage of sperm head abnormalities was noted but when animals primed with Phyllanthus fruit extract (PFE), a reduction in the frequency of sperm head abnormalities was observed. It can be suggested from the above study that Phyllanthus emblica plays a key role in inhibition of heavy metal mutagenesis in mammals.